ALERT

For the latest coronavirus care instructions and resources, please call our COVID-19 hotline at 208-381-9500. Find additional information and resources here and learn more about how we’re working to keep you healthy and safe.

toggle mobile menu Menu
toggle search menu

Site Navigation

Supplemental

Menu

Apolipoprotein E-4 Genetic (DNA) Test

Apolipoprotein E-4 Genetic (DNA) Test

Topic Overview

Most people who develop Alzheimer's disease do not have a history of the disease in their families. But if you do have a family history of Alzheimer's disease (one or more members of a family have had the disease), then your risk of getting it is higher. When a disease is found in families, the cause could be genetic (heredity), something in the environment, lifestyle choices, or a combination of these things.

A blood test can look for a substance that seems to increase a person's risk for Alzheimer's disease. The gene is called apolipoprotein E-4 (ApoE-4). The presence of ApoE-4 cannot predict for sure whether a person will develop Alzheimer's disease. Many people who have the ApoE-4 gene do not get Alzheimer's disease, and many people who do not have the gene still develop the disease. Most experts do not consider ApoE-4 testing a necessary or useful part of evaluating a person with suspected Alzheimer's disease.

Early-onset Alzheimer's

Sometimes people develop Alzheimer's disease at a young age, between the ages of 30 and 60. This is referred to as early-onset Alzheimer's disease or autosomal dominant Alzheimer's disease. It is not common (less than 5 out of 100 cases), and this form of the disease has been linked to defects in specific genes. There is a 50% risk that these genes will be passed on. A person who inherits the genetic defect will most likely develop Alzheimer's disease.

Related Information

Credits

Current as of: January 31, 2020

Author: Healthwise Staff
Medical Review: Anne C. Poinier MD - Internal Medicine
Kathleen Romito MD - Family Medicine
Myron F. Weiner MD - Psychiatry, Neurology

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Healthwise is a URAC accredited health web site content provider. Privacy Policy. How this information was developed to help you make better health decisions.

© 1995-2015 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.