ALERT

For the latest coronavirus care instructions and resources, please call our COVID-19 hotline at 208-381-9500. Find additional information and resources here and learn more about how we're working to keep you healthy and safe.

toggle mobile menu Menu
toggle search menu

Site Navigation

Supplemental

Menu

Indirect Coombs Test

Topic Overview

An indirect Coombs test can be used to determine whether there are antibodies to the Rh factor in the mother's blood. In this case:

  • A normal (negative) result means that the mother has not developed antibodies against the fetus's blood. A negative Coombs test indicates that the fetus is not presently in danger from problems relating to Rh incompatibility.
  • An abnormal (positive) result means that the mother has developed antibodies to the fetal red blood cells and is sensitized. However, a positive Coombs test only indicates that an Rh-positive fetus has a possibility of being harmed. A positive test cannot indicate the amount of fetal harm that has occurred or is likely to occur.

If test results show that antibody amounts are increasing during pregnancy, the fetus may be at greater risk of harm.

A fetus who is Rh-negative will not be harmed, even if the mother is sensitized.

Credits

Current as of: February 11, 2020

Author: Healthwise Staff
Medical Review: Sarah Marshall MD - Family Medicine
E. Gregory Thompson MD - Internal Medicine
Adam Husney MD - Family Medicine
Kathleen Romito MD - Family Medicine
Elizabeth T. Russo MD - Internal Medicine
Kirtly Jones MD - Obstetrics and Gynecology

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Healthwise is a URAC accredited health web site content provider. Privacy Policy. How this information was developed to help you make better health decisions.

© 1995-2015 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.